2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-134675
    THP-PEG4-C1-OH
    THP-PEG4-C1-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG4-C1-OH
  • HY-133462
    Tetrazine-Ph-NHCO-PEG4-NH-Boc
    Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-PEG4-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-NHCO-PEG4-NH-Boc
  • HY-141168
    TCO-PEG6-NHS ester 2353409-96-6
    TCO-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    TCO-PEG6-NHS ester
  • HY-140990
    6-Maleimidocaproic acid-PFP ester 692739-25-6
    6-Maleimidocaproic acid-PFP ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    6-Maleimidocaproic acid-PFP ester
  • HY-140292
    DBCO-PEG9-NH-Boc
    DBCO-PEG9-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG9-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG9-NH-Boc
  • HY-168552
    3-Hydroxyazetidine-Cyclohexanol 1553176-51-4
    3-Hydroxyazetidine-Cyclohexanol is a PROTAC linker that can be used in the synthesis of ALK PROTAC (HY-168551).
    3-Hydroxyazetidine-Cyclohexanol
  • HY-W096066
    Benzyl-PEG8-THP 1611489-00-9
    Benzyl-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG8-THP
  • HY-130669
    Ald-Ph-amido-C2-PEG3-NH-Boc 1807540-87-9
    Ald-Ph-amido-C2-PEG3-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ald-Ph-amido-C2-PEG3-NH-Boc
  • HY-140082
    Hydroxy-Amino-bis(PEG2-propargyl) 2100306-77-0
    Hydroxy-Amino-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Hydroxy-Amino-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Hydroxy-Amino-bis(PEG2-propargyl)
  • HY-126950
    Aminooxy-PEG4-azide 2100306-61-2
    Aminooxy-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Aminooxy-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Aminooxy-PEG4-azide
  • HY-138526
    Thiol-C9-PEG4-acid 716339-41-2
    Thiol-C9-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-C9-PEG4-acid
  • HY-141385
    N-Succinimidyl 3-(Bromoacetamido)propionate 57159-62-3
    N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Succinimidyl 3-(Bromoacetamido)propionate
  • HY-138355
    CHO-CH2-PEG1-CH2-Boc 2230956-95-1
    CHO-CH2-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    CHO-CH2-PEG1-CH2-Boc
  • HY-140354
    Azide-PEG7-Tos 1418561-41-7
    Azide-PEG7-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG7-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG7-Tos
  • HY-132017
    Bromo-PEG4-NHS ester 2148295-98-9
    Bromo-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG4-NHS ester
  • HY-130831
    Hydroxy-PEG12-Boc 2388521-20-6
    Hydroxy-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG12-Boc
  • HY-140813
    Azido-PEG3-phosphonic acid ethyl ester 1337527-24-8
    Azido-PEG3-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-phosphonic acid ethyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-phosphonic acid ethyl ester
  • HY-140767
    Azido-PEG8-C1-NHS ester 2182601-81-4
    Azido-PEG8-C1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-C1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-C1-NHS ester
  • HY-138712
    Benzyl-PEG9-Ots 393517-91-4
    Benzyl-PEG9-Ots is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG9-Ots
  • HY-140885
    Boc-NH-PEG12-propargyl
    Boc-NH-PEG12-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG12-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Boc-NH-PEG12-propargyl
PROTAC Linkers Isoform Comparison

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