2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-132017
    Bromo-PEG4-NHS ester 2148295-98-9
    Bromo-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG4-NHS ester
  • HY-130831
    Hydroxy-PEG12-Boc 2388521-20-6
    Hydroxy-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG12-Boc
  • HY-140813
    Azido-PEG3-phosphonic acid ethyl ester 1337527-24-8
    Azido-PEG3-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-phosphonic acid ethyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-phosphonic acid ethyl ester
  • HY-140767
    Azido-PEG8-C1-NHS ester 2182601-81-4
    Azido-PEG8-C1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-C1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-C1-NHS ester
  • HY-138712
    Benzyl-PEG9-Ots 393517-91-4
    Benzyl-PEG9-Ots is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG9-Ots
  • HY-140885
    Boc-NH-PEG12-propargyl
    Boc-NH-PEG12-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG12-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Boc-NH-PEG12-propargyl
  • HY-115392
    Ms-PEG12-m 1059604-93-1
    Ms-PEG12-m is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ms-PEG12-m
  • HY-141315
    m-PEG6-C6-phosphonic acid ethyl ester 2028281-88-9
    m-PEG6-C6-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG6-C6-phosphonic acid ethyl ester
  • HY-132016
    Benzyl-PEG8-NHS ester
    Benzyl-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG8-NHS ester
  • HY-141404
    m-PEG4-CH2-methyl ester 1920109-55-2
    m-PEG4-CH2-methyl ester is a PEG- and Alkyl/ester-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG4-CH2-methyl ester
  • HY-133468
    Methyltetrazine-PEG6-maleimide
    Methyltetrazine-PEG6-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-PEG6-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Methyltetrazine-PEG6-maleimide
  • HY-140378
    t-Boc-Aminooxy-PEG8-MS
    t-Boc-Aminooxy-PEG8-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-Aminooxy-PEG8-MS
  • HY-140851
    Azido-PEG1-methyl ester 1835759-80-2
    Azido-PEG1-methyl ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-methyl ester
  • HY-140159
    Methylamino-PEG5-azide 2055046-24-5
    Methylamino-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methylamino-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Methylamino-PEG5-azide
  • HY-138377
    Azido-PEG8-C-Boc 1984776-39-7
    Azido-PEG8-C-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-C-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-C-Boc
  • HY-126916
    Tetrahydropyranyldiethyleneglycol 2163-11-3
    Tetrahydropyranyldiethyleneglycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tetrahydropyranyldiethyleneglycol
  • HY-140016
    Bis-(m-PEG4)-amidohexanoic acid 2353409-74-0
    Bis-(m-PEG4)-amidohexanoic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-(m-PEG4)-amidohexanoic acid
  • HY-140870
    N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) 2093152-79-3
    N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester)
  • HY-W096160
    Bis-acrylate-PEG5 59256-52-9
    Bis-acrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-acrylate-PEG5
  • HY-141092
    Pyrene-PEG2-azide 2135330-58-2
    Pyrene-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Pyrene-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Pyrene-PEG2-azide
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.